Returning to South Florida after Living in the Philippines

Florida native, lived in Jacksonville, Gainesville (UofF), Miami Beach, Sunny Isles Beach, and Bay Harbor at one time or another — over a decade ago. I'm expanding my business back into South Florida, and I'm looking for suggestions for a good place to spend 1/3-1/2 my time. Cost is a factor, but so is quality of life. Any suggestions?