Can certain medications make it harder to get high on edibles?

I tried some edibles to partake for the first time in 10 years a few months ago and I've read online to start at 2mg but even taking up to 6mg of edibles had me barely feeling a thing for the whole day. The high was honestly pretty boring. So I'm wondering if some medications I'm on can reduce the effectiveness of getting high or at least edibles? I'm on a mood stabilizer/anti-epileptic, anti-psychotic, and ssri for reference.

I'm wondering if maybe an edible high wasn't for me because I was hoping for euphoria and I just got really chill and barely felt anything. I'm going to try smoking a joint with my friend and see how the high differs. Could someone shed some light?